Adiposopathy or "sick fat" emerges when adipose tissue responds to positive caloric balance with pathogenic anatomic, endocrine, and immune responses that promote metabolic diseases such as type 2 diabetes mellitus, high blood pressure, and dyslipidemia.
Adiposopathy ("Sick Fat") and Its Relationship to Metabolic Disease
Definition: Adiposopathy ("sick fat") is defined as pathogenic anatomic adipose tissue changes that may occur with positive caloric balance, which results in pathophysiologic endocrine and immune responses that promote metabolic disease.